Oesophageal Cancer

The oesophagus is a long tube that delivers food, fluids and saliva from the mouth and throat to the stomach.

Adenocarcinoma is the most common type of oesophageal cancer and occurs in glandular tissue, most often in the lower part of the oesophagus near the stomach.

These are often associated with precancerous change as a result of long term reflux and acid damage to the lower oesophagus.

Squamous cell carcinoma occurs in the cells lining the oesophagus. This type of oesophageal cancer is more common in smokers, African-Americans and in people of Asian descent.


Oesophageal cancer rates are fairly stable in Australia.

  • Oesophageal cancer is more common among men, being 3 to 4 times more likely to develop it.
  • Approximately 20% of people with oesophageal cancer will survive 5 years after diagnosis.

Every patient is different, speak to your doctor or refer to our tips on how to find the right specialist to ensure you find the answers you are looking for.


Some risk factors associated with this cancer include:

  • Smoking: Long-term history of smoking.
  • Alcohol: Consumption of alcohol, especially when combined with smoking.
  • Barrett’s Oesophagus: a condition in which chronic acid reflux causes changes in the cells lining the lower oesophagus, increasing the risk of adenocarcinoma.
  • Achalasia: a disease in which the oesophagus fails to move food into the stomach properly.
  • Tylosis: a rare, inherited disorder that causes excess skin to grow on the soles of the feet and palms and has a near 100% chance of developing into oesophageal cancer.
  • Lye or other caustic substances: when ingested, such substances can cause scarring that may progress to cancer years later.



Signs and symptoms of this type of cancer may include:

  • Difficulty swallowing
  • Pain, pressure or burning in the throat or chest
  • Weight loss
  • Vomiting
  • Harsh, raspy or strained voice


Various investigations may be performed depending on the symptoms leading to the diagnosis of cancer and for determination of the extent of cancer.

Some tests that may be performed according to the cancer type include:

  • Image tests
  • Barium swallow
  • MRI, CT and PET scan
  • Endoscopy


Once the diagnosis is made, cancer removal when possible would be the best treatment option in the majority of cases.

Treatment for oesophageal cancer depends on the stage.  In the instance where an operation is not possible or beneficial, insertion of an oesophageal stent may be utilised for palliation of dysphagia.

Surgery is the most common treatment for esophageal cancer. There are two surgical techniques:

  • Open radical oesophagectomy: The cancerous portions of the oesophagus, top portion of the stomach and neighboring lymph nodes are removed.
  • Minimally invasive oesophagectomy: Keyhole operation to achieve similar results to the standard open radical approach.

Depending on the type of tumor, chemotherapy which involves the use of drugs to kill cancer cells, is most often combined with radiation therapy.

Endomucosal resection can be an option for very early tumors, particularly in patients unlikely to tolerate major surgery.

Other potential treatments available for pre-cancerous growths include Photodynamic therapy (PDT), Argon Plasma (APC) or Radio Frequency Ablation (RFA), each is explained below:

Photodynamic therapy: laser-sensitive chemicals are injected into the tumor site. A laser beam then targets the chemicals to destroy the tumor. This therapy is more commonly utilised for treatment of more pre-cancers in high risk regions or when surgery is not possible for palliative purposes.

Argon plasma: This therapy involves direct thermal injury to precancerous cells. The body then recovers and replenishes the area of injury with normal cells.

Radio Frequency Ablation: This utilises a radio frequency generator via a probe (device), the energy is transmitted to the target tissue causing it to heat up. The heat destroys the target tissue and the body replenishes it with normal cells.

Find a specialist

Click here to read our tips on finding the right specialist for you.